According to Mikhail Blagosklonny, scientist, oncologist, professor, and Editor-in-Chief at Oncotarget says with age, the repair mechanisms of the body diminish. As a result, wear and tear increases and it increases the risk of diseases such as Alzheimer’s, diabetes or disorders of the cardiovascular system. Current therapies are based on treating these diseases, but if you ask Mikhail Blagosklonny, doctors should be consider a strategy that addresses aging, rather than age-related diseases. But how do you accomplish that?
Increasing Our Life Span
The drug Rapamycin is incredible, says Dr. Blagosklonny. It’s used in organ transplantation to keep the immune system in check, and thus can prevent rejection of foreign tissue. Scientists have demonstrated another effect, or an added bonus of Rapamycin. This drug was the first drug that has shown an effect on the maximum life span in mice, and has prompted additional clinical studies. Rapamycin also inhibits tumor formation.
“Aging is a complex process,” Dr. Mikhail Blagosklonny explains. “It causes so many changes in the cells, and organs, and behavior,” he added. Over the years, our body’s ability decreases to form new cells. Thus, the whole metabolism slows down. It is quite natural that many functions we take for granted slowly decrease. For example, eyesight and hearing: Over the years, the human is eye not as good in different lighting conditions. In addition, from about the age of 40 individuals can develop presbyopia. And the immune system doesn’t produce as many antibodies and new cells. Thus, older people are more likely to get sick and it is more common that it becomes severe over the course of the disease.
The Roswell Park Cancer Institute professor has been researching Rapamycin also known as Sirolimus for this revolutionary potential of slowing down the aging process. Clinical studies have shown that the life expectancy of treated mice increased by 14 percent. Currently, researchers at the University of Washington Seattle are testing Rapamycin on dogs. The search for drugs that slow the aging process is cumbersome in, but also promising. Dr. Blagosklonny says Rapamycin can be used to prevent restenosis, after a balloon angioplasty medical procedure. In fact, tests have showed that patients using the drug after their angioplasty procedure did not require a repeat of the procedure, due to the use of the drug.
Additionally, the drug inhibits cancerous tumors, while providing a boost to the immune system, which in turn, helps the body fight off the disease. Blagosklonny believes that if cell aging can stop, organs will work longer, enabling a longer lifespan.
Dr.MikhailBlagosklonny, a Professor of Oncology is a highly experienced researcher with an acclaimed career. After graduating with his M.D. and Ph.D. from the First Pavlov State Medical University of St. Petersburg, he moved to the United States, and worked at NY Medical College. He served as an Associate Professor of Medicine before being appointed Senior Scientist at Ordway Research Institute in 2002. After seven years, Dr. Blagosklonny left to become Professor of Oncology at Roswell Park Cancer Institute. Through his research there, he studies cancer and aging.